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001			00012595
003			WSP
005			20250414083509.0
007			cr |nu|||unuuu
008			230815s2024 si ob 001 0 eng d
010			_a 2023016775
020			_a9789811248665 _q(ebook)
020			_a9811248664 _q(ebook)
020			_z9789811248658 _q(hbk.)
040			_aWSPC _beng _cWSPC
050		4	_aRC268.4
072		7	_aSCI _x007000 _2bisacsh
072		7	_aMED _x062000 _2bisacsh
072		7	_aSCI _x017000 _2bisacsh
082	0	4	_a616.99/4042 _223
049			_aMAIN
245	0	0	_aRNA-based mechanisms in cancer _h[electronic resource] / _ceditors, Gary Brewer, Gerald M Wilson.
260			_aSingapore : _bWorld Scientific, _cc2024.
300			_a1 online resource (.xv, 496 p.)
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to RNA and cancer -- Aberrant RNA splicing and therapeutic reprogramming in cancer -- Alternative 3'-RNA processing in cancer -- Tandem CCCH zinc finger RNA-binding proteins and their roles in tumor progression -- Roles of the Hu/ELAV family of mRNA-stabilizing proteins in tumor development -- Pro- and anti-tumorigenic activities of the RNA-binding protein AUF1 -- Oncogenic consequences of dysregulated translation initiation -- The mTOR complexes: coordinating metabolism and translation -- Therapeutic potential of inhibiting mTOR signaling in neoplasia -- Roles of microRNAs in hematologic malignancies -- Long noncoding RNAs in inflammation, cancer, and in cancer therapy -- The epitranscriptome and cancer -- miRNA-based therapeutic strategies.
520			_a"The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression. We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address "where do we go from here" and stimulate the reader's thinking about these important problems. This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics"-- _cPublisher's website.
538			_aMode of access: World Wide Web.
538			_aSystem requirements: Adobe Acrobat Reader.
650		0	_aCancer _xGenetic aspects.
650		0	_aCatalytic RNA.
650		0	_aHuman genetics.
655		0	_aElectronic books.
700	1		_aBrewer, Gary _q(Gary A.)
700	1		_aWilson, Gerald M.
856	4	0	_uhttps://www.worldscientific.com/worldscibooks/10.1142/12595#t=toc _zAccess to full text is restricted to subscribers.
999			_c10046 _d10046