RNA-based mechanisms in cancer [electronic resource] / editors, Gary Brewer, Gerald M Wilson.
Material type:
- 9789811248665
- 9811248664
- 616.99/4042 23
- RC268.4
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Centerville | Available | 1000000338 | |
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Centerville | Available | 1000000340 |
Includes bibliographical references and index.
Introduction to RNA and cancer -- Aberrant RNA splicing and therapeutic reprogramming in cancer -- Alternative 3'-RNA processing in cancer -- Tandem CCCH zinc finger RNA-binding proteins and their roles in tumor progression -- Roles of the Hu/ELAV family of mRNA-stabilizing proteins in tumor development -- Pro- and anti-tumorigenic activities of the RNA-binding protein AUF1 -- Oncogenic consequences of dysregulated translation initiation -- The mTOR complexes: coordinating metabolism and translation -- Therapeutic potential of inhibiting mTOR signaling in neoplasia -- Roles of microRNAs in hematologic malignancies -- Long noncoding RNAs in inflammation, cancer, and in cancer therapy -- The epitranscriptome and cancer -- miRNA-based therapeutic strategies.
"The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression. We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address "where do we go from here" and stimulate the reader's thinking about these important problems. This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics"-- Publisher's website.
Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
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